Theoretical Genetics
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Theoretical Genetics
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  • Define:

    Genotype

    The alleles possessed by an organism

    Phenotype

    All the characteristics of an organism

    Dominant allele

    An allele which has the same effect on the phenotype whether it is present in the homozygous or heterozygous state

    Recessive allele

    An allele which only has an effect on the phenotype when present in homozygous state

    Codominant alleelle

    Allelees which have a partial effect on the phenotype when present in heterozygotes but a greater effect in homozygotes

    Locus

    The particular position on homologous chromosomes of a gene

    Homozygous

    Having two identical alleles of a gene

    Heterozygous

    Having two different alleles of a gene

    Carrier

    An individual that has a recessive allele of a gene that does not have an effect on the phenotype

    Test Cross

    Testing a suspected heterozygote by crossing with a known homozygous recessive

    Punnet Grid

     

    Pedigree Chart

    a record of ancestry or purity of breed

    State that some genes have more than two alleles

    Describe ABO blood groups as an example of co-dominance and multiple alleles

    Co-dominant alleles- alleles which have a partial effect on the

    phenotype when present in heterozygous state but have a greater effect in

    homozygotes.

    An example is in the alleles controlling the BO blood group system in humans.

    The ABO system is controlled by 3 alleles; I , I and I .

    I produces A antigens

    I produces B antigens

    I produces no antigens

    There are 2 such alleles present in each person and therefore 6 combinations,

    which are:

    I I = A

    I I = A The I and I alleles show equal dominance

    I I = B with respect to one another (i.e. the are

    I I = AB co-dominant), but each is dominant to I .

    I I = O Inheritance follows normal Mendelian

    I I = B patterns.

     

    Outline how the sex chromosomes determine gender by referring to the inheritance of x and y chromosomes of humans

    Xy = male

    Xx = female

    State that some genes are present on the x chromosome and absent from the shorter y chromosome

    Define sex linkage

    Genes carried on sex chromosomes

     

    State two examples of sex linkage

  • Colour Blindness

  • Haemophilia

    State that a human female can be heterozygous or homozygous, with respect to sex-linked genes

    Explain that female carriers are heterozygous for x-linked alleles

    Calculate and predict the genotypic and phenotypic ratios of offspring of monohybrid crosses involving any of the above patterns of inheritance

    Deduce the genotypes or phenotypes of individuals in pedigree charts

  • Other Notes in this Category

    1. Applied Genetics
    2. Chromosomes, genes and alleles
    3. Gene Mutation
    4. Meiosis
    5. Theoretical Genetics

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